Cajun-Spiced Shrimp Po'Boy Sandwich
A classic Louisiana sandwich featuring crispy Cajun-seasoned shrimp nestled in a soft hoagie roll with tangy remoulade and fresh lettuce. This american-inspired sandwiches & wraps ready in about 30 minutes pairs large shrimp, peeled and deveined, cajun seasoning, all-purpose flour for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 480 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.
Ingredients
- 1 lb large shrimp, peeled and deveined
- 2 tbsp cajun seasoning
- 1 cup all-purpose flour
- 3/4 cup buttermilk
- 2 cups vegetable oil
- 4 hoagie rolls
- 1 cup romaine lettuce, shredded
- 1 medium tomato, sliced
- 1/2 cup mayonnaise
- 1 tbsp prepared horseradish
- 1 tbsp lemon juice
- 1 tsp hot sauce
- 1/2 tsp garlic powder
- 1/2 tsp paprika
- to taste salt
- to taste black pepper
Instructions
- Step 1: Rinse and pat dry 1 lb large shrimp, then toss with 2 tbsp Cajun seasoning to coat evenly.
- Step 2: Pour 3/4 cup buttermilk into a bowl and place 1 cup all-purpose flour in another shallow dish.
- Step 3: Heat 2 cups vegetable oil in a deep skillet over medium-high heat until it reaches 350°F.
- Step 4: Dip each shrimp first into the buttermilk, then dredge thoroughly in flour, shaking off excess.
- Step 5: Fry shrimp in batches for 2-3 minutes until golden and cooked through, then drain on paper towels.
- Step 6: In a small bowl, whisk together 1/2 cup mayonnaise, 1 tbsp prepared horseradish, 1 tbsp lemon juice, 1 tsp hot sauce, 1/2 tsp garlic powder, 1/2 tsp paprika, salt, and black pepper to taste until smooth.
- Step 7: Slice 4 hoagie rolls lengthwise without cutting all the way through and lightly toast them.
- Step 8: Spread a generous layer of the remoulade sauce inside each roll, then layer with 1 cup shredded romaine lettuce, sliced tomato, and the fried shrimp.
- Step 9: Serve immediately for a crunchy, spicy, and tangy po'boy experience.
Frequently asked questions
How long does Cajun-Spiced Shrimp Po'Boy Sandwich take to make?
Total time is about 30 minutes (15 min prep + 15 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.
How do I store leftover Cajun-Spiced Shrimp Po'Boy Sandwich?
Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep cajun seasoning from drying out.
Can I substitute ingredients in Cajun-Spiced Shrimp Po'Boy Sandwich?
Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.
How do I scale Cajun-Spiced Shrimp Po'Boy Sandwich for a different number of people?
The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.
What goes well with Cajun-Spiced Shrimp Po'Boy Sandwich?
American sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.
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