Cajun-Spiced Shrimp Po'boy with Remoulade Sauce
A Southern sandwich featuring crispy Cajun-spiced shrimp nestled in a soft sub roll with a tangy homemade remoulade sauce and fresh lettuce. This southern-inspired sandwiches & wraps ready in about 30 minutes blends medium shrimp, peeled and deveined, Cajun seasoning, all-purpose flour into a versatile sauce that lifts everything from grain bowls and roasted vegetables to grilled proteins — a small-batch staple worth keeping in the fridge. Each serving lands at about 450 calories and feeds 4, so a small batch covers several meals across the week without taking over the fridge. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.
Ingredients
- 1 lb medium shrimp, peeled and deveined
- 2 tbsp Cajun seasoning
- 1/2 cup all-purpose flour
- 3/4 cup buttermilk
- 2 cups vegetable oil
- 4 sub rolls
- 1 cup shredded iceberg lettuce
- 1 medium tomato, thinly sliced
- 1/2 cup mayonnaise
- 1 tbsp Dijon mustard
- 1 tsp prepared horseradish
- 1 tsp Worcestershire sauce
- 1 tbsp lemon juice
- 1 tsp paprika
- 1/2 tsp garlic powder
- to taste salt
- to taste black pepper
Instructions
- Step 1: In a medium bowl, toss 1 lb peeled and deveined medium shrimp with 2 tbsp Cajun seasoning, coating evenly. Set aside.
- Step 2: Pour 3/4 cup buttermilk into a shallow dish. In another dish, place 1/2 cup all-purpose flour for dredging.
- Step 3: Heat 2 cups vegetable oil in a deep skillet over medium-high heat until it reaches 350°F.
- Step 4: Dip each shrimp first into the buttermilk, then dredge in flour, shaking off excess.
- Step 5: Fry shrimp in batches for 2-3 minutes until golden and crispy, then transfer to a paper towel-lined plate to drain.
- Step 6: In a small bowl, whisk together 1/2 cup mayonnaise, 1 tbsp Dijon mustard, 1 tsp prepared horseradish, 1 tsp Worcestershire sauce, 1 tbsp lemon juice, 1 tsp paprika, and 1/2 tsp garlic powder to make the remoulade sauce. Season with salt and black pepper to taste.
- Step 7: Slice 4 sub rolls lengthwise and toast lightly if desired. Spread a generous layer of remoulade sauce on both sides.
- Step 8: Layer each roll with 1/4 cup shredded iceberg lettuce, 3-4 slices of tomato, and a generous portion of fried shrimp.
- Step 9: Close sandwiches and serve immediately while shrimp are hot and crisp.
Frequently asked questions
How long does Cajun-Spiced Shrimp Po'boy with Remoulade Sauce take to make?
Total time is about 30 minutes (15 min prep + 15 min cook). A small batch typically covers several meals in the week — store as the recipe directs.
How do I store leftover Cajun-Spiced Shrimp Po'boy with Remoulade Sauce?
Transfer to an airtight jar and refrigerate for up to 5–7 days. Most sauces freeze well for up to 2 months — portion into small containers or freezer bags so you can thaw only what you need. Stir before serving; cream- or yogurt-based sauces may separate on standing.
Can I substitute ingredients in Cajun-Spiced Shrimp Po'boy with Remoulade Sauce?
Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.
How do I scale Cajun-Spiced Shrimp Po'boy with Remoulade Sauce for a different number of people?
The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.
What goes well with Cajun-Spiced Shrimp Po'boy with Remoulade Sauce?
Southern sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.
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