Grilled Cajun-Spiced Chicken Sandwich with Remoulade Sauce

By AislePrompt Test Kitchen · Reviewed by AislePrompt Editorial · ·

A smoky grilled chicken breast generously coated in Cajun spices served on a toasted bun with crisp lettuce and a tangy homemade remoulade sauce. This southern us-inspired sandwiches & wraps ready in about 30 minutes blends cajun seasoning, olive oil, burger buns into a versatile sauce that lifts everything from grain bowls and roasted vegetables to grilled proteins — a small-batch staple worth keeping in the fridge. Each serving lands at about 520 calories and feeds 4, so a small batch covers several meals across the week without taking over the fridge. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 15 min Serves 4 Southern US cuisine 520 cal/serving
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Ingredients

Instructions

  1. Step 1: Preheat grill to medium-high heat (about 400°F). Brush 4 boneless skinless chicken breasts with 2 tbsp olive oil, then rub evenly with 3 tbsp Cajun seasoning covering all sides.
  2. Step 2: Grill chicken breasts for 6-7 minutes per side until internal temperature reaches 165°F and grill marks appear, then remove and let rest for 5 minutes.
  3. Step 3: While chicken cooks, mix 1/2 cup mayonnaise, 2 tbsp Dijon mustard, 1 tbsp hot sauce, 1 tbsp lemon juice, 1/2 tsp garlic powder, 1/2 tsp paprika, 1/4 tsp black pepper, and 1/4 tsp salt in a bowl to make remoulade sauce.
  4. Step 4: Lightly toast 4 burger buns on the grill for 1-2 minutes until golden. Spread remoulade sauce on the bottom buns, top with lettuce leaves and grilled chicken breasts, then cover with top buns and serve immediately.

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Frequently asked questions

How long does Grilled Cajun-Spiced Chicken Sandwich with Remoulade Sauce take to make?

Total time is about 30 minutes (15 min prep + 15 min cook). A small batch typically covers several meals in the week — store as the recipe directs.

How do I store leftover Grilled Cajun-Spiced Chicken Sandwich with Remoulade Sauce?

Transfer to an airtight jar and refrigerate for up to 5–7 days. Most sauces freeze well for up to 2 months — portion into small containers or freezer bags so you can thaw only what you need. Stir before serving; cream- or yogurt-based sauces may separate on standing.

Can I substitute ingredients in Grilled Cajun-Spiced Chicken Sandwich with Remoulade Sauce?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Grilled Cajun-Spiced Chicken Sandwich with Remoulade Sauce for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Grilled Cajun-Spiced Chicken Sandwich with Remoulade Sauce?

Southern US sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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