Sheet Pan Cajun-Spiced Brisket with Roasted Vegetables

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

Tender brisket infused with bold Cajun spices roasted alongside a medley of root vegetables for a hearty, one-pan meal. This bbq & smoked-inspired beef ready in about 200 minutes pairs beef brisket, olive oil, smoked paprika for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 450 calories and feeds 6, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 20 min Cook: 180 min Serves 6 450 cal/serving
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Ingredients

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Instructions

  1. Step 1: Preheat the oven to 325°F. In a small bowl, combine 2 tsp smoked paprika, 1 tsp cayenne pepper, 1 tsp garlic powder, 1 tsp onion powder, 1 tsp dried thyme, 1 tsp salt, and 1 tsp black pepper. Rub this Cajun spice mix all over 2 lbs beef brisket evenly.
  2. Step 2: On a large sheet pan, toss 3 medium peeled and chunked carrots, 4 quartered red potatoes, and 1 large wedge-cut yellow onion with 3 tbsp olive oil and a pinch of salt until well coated. Arrange the vegetables in an even layer.
  3. Step 3: Place the seasoned brisket on top of the vegetables. Roast uncovered in the preheated oven for 3 hours, basting the brisket with pan juices every hour, until the meat is tender and vegetables are roasted.
  4. Step 4: Remove the pan from the oven and let the brisket rest for 15 minutes before slicing thinly against the grain. Garnish with 2 tbsp chopped fresh parsley and serve warm with the roasted vegetables.

Frequently asked questions

How long does Sheet Pan Cajun-Spiced Brisket with Roasted Vegetables take to make?

Total time is about 200 minutes (20 min prep + 180 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Sheet Pan Cajun-Spiced Brisket with Roasted Vegetables?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep beef brisket from drying out.

Can I substitute ingredients in Sheet Pan Cajun-Spiced Brisket with Roasted Vegetables?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Sheet Pan Cajun-Spiced Brisket with Roasted Vegetables for a different number of people?

The recipe is written for 6 servings. Multiply each ingredient by (your serving target / 6). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Sheet Pan Cajun-Spiced Brisket with Roasted Vegetables?

BBQ & Smoked beef like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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