Slow Cooker Mississippi-Style Beef Roast with Pepperoncini

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

A tender beef roast slow-cooked with pepperoncini peppers and a simple spice blend, creating a flavorful and juicy meal. This american-inspired beef ready in about 495 minutes pairs beef chuck roast, salt, black pepper for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 380 calories and feeds 6, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 480 min Serves 6 American cuisine 380 cal/serving
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Ingredients

Instructions

  1. Step 1: Season 3 lbs beef chuck roast evenly with 1 tsp salt, 1/2 tsp black pepper, 1 tsp garlic powder, and 1 tsp onion powder on all sides.
  2. Step 2: Place the seasoned roast in the slow cooker and top with 1/4 cup unsalted butter, 1 packet ranch seasoning mix, and 1 packet au jus gravy mix.
  3. Step 3: Add 8 whole pepperoncini peppers along with 1/4 cup of their juice over the roast.
  4. Step 4: Cover and cook on low for 8 hours or on high for 4-5 hours, until the beef is fork-tender and shreds easily.
  5. Step 5: Remove the roast and shred with two forks, mixing it with the juices in the slow cooker before serving warm.

Equipment for this recipe

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Frequently asked questions

How long does Slow Cooker Mississippi-Style Beef Roast with Pepperoncini take to make?

Total time is about 495 minutes (15 min prep + 480 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Slow Cooker Mississippi-Style Beef Roast with Pepperoncini?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep beef chuck roast from drying out.

Can I substitute ingredients in Slow Cooker Mississippi-Style Beef Roast with Pepperoncini?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Slow Cooker Mississippi-Style Beef Roast with Pepperoncini for a different number of people?

The recipe is written for 6 servings. Multiply each ingredient by (your serving target / 6). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Slow Cooker Mississippi-Style Beef Roast with Pepperoncini?

American beef like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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