Spicy Po’Boy Sandwich with Fried Catfish and Remoulade

By AislePrompt Test Kitchen · Reviewed by AislePrompt Editorial · ·

A classic New Orleans sandwich featuring crispy fried catfish, crisp lettuce, tomato slices, and a zesty remoulade sauce on a French roll. This louisiana creole-inspired sandwiches & wraps ready in about 45 minutes pairs catfish fillets, buttermilk, all-purpose flour for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 550 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 30 min Cook: 15 min Serves 4 Louisiana Creole cuisine 550 cal/serving
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Ingredients

Instructions

  1. Step 1: In a shallow dish, combine 1 cup buttermilk with 1 tbsp Cajun seasoning. Submerge 1 lb catfish fillets and marinate for 20 minutes.
  2. Step 2: In another bowl, mix 1 cup all-purpose flour, 1/2 cup cornmeal, and 1 tsp paprika.
  3. Step 3: Heat 2 cups vegetable oil in a deep skillet over medium-high heat until it reaches 350°F.
  4. Step 4: Remove catfish from buttermilk, dredge in flour-cornmeal mixture, shaking off excess.
  5. Step 5: Fry catfish in hot oil for 3-4 minutes per side until golden brown and crispy. Drain on paper towels.
  6. Step 6: For remoulade sauce, whisk together 1/2 cup mayonnaise, 1 tbsp Dijon mustard, 1 tsp prepared horseradish, 1 tbsp hot sauce, 1 tbsp lemon juice, and 1 tsp minced garlic until smooth.
  7. Step 7: Slice 4 French rolls lengthwise, spread remoulade sauce generously inside each roll.
  8. Step 8: Layer each roll with fried catfish, 1 cup shredded iceberg lettuce, and 1 cup sliced tomatoes.
  9. Step 9: Serve immediately while hot and crisp.

Equipment for this recipe

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Frequently asked questions

How long does Spicy Po’Boy Sandwich with Fried Catfish and Remoulade take to make?

Total time is about 45 minutes (30 min prep + 15 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Spicy Po’Boy Sandwich with Fried Catfish and Remoulade?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep catfish fillets from drying out.

Can I substitute ingredients in Spicy Po’Boy Sandwich with Fried Catfish and Remoulade?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Spicy Po’Boy Sandwich with Fried Catfish and Remoulade for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Spicy Po’Boy Sandwich with Fried Catfish and Remoulade?

Louisiana Creole sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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