Cajun-Spiced Po’ Boy Sandwich with Remoulade Sauce

By AislePrompt Test Kitchen · Reviewed by AislePrompt Editorial · ·

A classic New Orleans sandwich featuring crispy fried shrimp seasoned with Cajun spices, served on a crusty baguette with zesty remoulade. This cajun-inspired sandwiches & wraps ready in about 35 minutes blends large shrimp, peeled and deveined, all-purpose flour, cornmeal into a versatile sauce that lifts everything from grain bowls and roasted vegetables to grilled proteins — a small-batch staple worth keeping in the fridge. Each serving lands at about 520 calories and feeds 4, so a small batch covers several meals across the week without taking over the fridge. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 20 min Cook: 15 min Serves 4 Cajun cuisine 520 cal/serving
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Ingredients

Instructions

  1. Step 1: In a medium bowl, whisk together 1 cup all-purpose flour, 1/2 cup cornmeal, and 2 tsp Cajun seasoning. Pour 1 cup buttermilk into a separate bowl.
  2. Step 2: Dip 1 lb peeled shrimp first into the buttermilk, then dredge evenly in the flour mixture, pressing lightly to coat.
  3. Step 3: Heat 2 cups vegetable oil in a deep skillet over medium-high heat until it reaches 350°F. Fry the shrimp in batches for 2-3 minutes until golden brown and crispy. Drain on paper towels.
  4. Step 4: In a small bowl, whisk 1/2 cup mayonnaise, 1 tbsp Dijon mustard, 1 tsp prepared horseradish, 1/2 tsp paprika, 1 tsp hot sauce, 1 tsp lemon juice, 1/4 tsp garlic powder, 1/4 tsp salt, and 1/4 tsp black pepper to make remoulade sauce.
  5. Step 5: Slice the baguette pieces lengthwise, spread each with remoulade, then layer with 1/4 cup shredded iceberg lettuce, 2-3 tomato slices, and a generous portion of fried shrimp. Serve immediately.

Equipment for this recipe

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Frequently asked questions

How long does Cajun-Spiced Po’ Boy Sandwich with Remoulade Sauce take to make?

Total time is about 35 minutes (20 min prep + 15 min cook). A small batch typically covers several meals in the week — store as the recipe directs.

How do I store leftover Cajun-Spiced Po’ Boy Sandwich with Remoulade Sauce?

Transfer to an airtight jar and refrigerate for up to 5–7 days. Most sauces freeze well for up to 2 months — portion into small containers or freezer bags so you can thaw only what you need. Stir before serving; cream- or yogurt-based sauces may separate on standing.

Can I substitute ingredients in Cajun-Spiced Po’ Boy Sandwich with Remoulade Sauce?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Cajun-Spiced Po’ Boy Sandwich with Remoulade Sauce for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Cajun-Spiced Po’ Boy Sandwich with Remoulade Sauce?

Cajun sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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