Cajun-Spiced Shrimp Po'Boys with Remoulade Sauce

By AislePrompt Test Kitchen · Reviewed by AislePrompt Editorial · Published 2026-05-12 · Updated 2026-05-12

A Southern classic sandwich featuring crispy Cajun-spiced shrimp nestled in a toasted French roll with a zesty remoulade sauce and fresh lettuce. This caribbean-inspired sandwiches & wraps ready in about 35 minutes blends peeled and deveined shrimp, Cajun seasoning, all-purpose flour into a versatile sauce that lifts everything from grain bowls and roasted vegetables to grilled proteins — a small-batch staple worth keeping in the fridge. Each serving lands at about 450 calories and feeds 4, so a small batch covers several meals across the week without taking over the fridge. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 1 lb, peeled and deveined shrimp
• 2 tbsp Cajun seasoning
• 1 cup all-purpose flour
• 1/2 cup buttermilk
• 2 cups, for frying vegetable oil
• 4, split French rolls
• 1 cup, shredded romaine lettuce
• 1/2 cup mayonnaise
• 1 tbsp Dijon mustard
• 1 tsp prepared horseradish
• 1 tsp hot sauce
• 1 tbsp lemon juice
• 1/2 tsp garlic powder
• 1/2 tsp paprika
• to taste salt
• to taste black pepper

Instructions

1. Step 1: In a medium bowl, toss 1 lb peeled and deveined shrimp with 2 tbsp Cajun seasoning until evenly coated; set aside.
2. Step 2: Pour 1/2 cup buttermilk into a shallow dish and place 1 cup all-purpose flour in another; dredge each shrimp first in flour, then dip into buttermilk, and again in flour to coat thoroughly.
3. Step 3: Heat 2 cups vegetable oil in a deep skillet over medium-high heat to 350°F; fry shrimp in batches for 2-3 minutes each until golden and crispy, then drain on paper towels.
4. Step 4: To make remoulade sauce, whisk together 1/2 cup mayonnaise, 1 tbsp Dijon mustard, 1 tsp prepared horseradish, 1 tsp hot sauce, 1 tbsp lemon juice, 1/2 tsp garlic powder, 1/2 tsp paprika, and salt and black pepper to taste until smooth and well combined.
5. Step 5: Lightly toast 4 French rolls under a broiler or in a toaster oven for 2 minutes until slightly crisp.
6. Step 6: Assemble sandwiches by spreading remoulade sauce on both sides of each roll, layering with 1 cup shredded romaine lettuce, then piling with the crispy Cajun shrimp; serve immediately.