Cranberry Orange Slow Cooker Pork Tenderloin

By AislePrompt Editorial · Published 2026-04-07 · Updated 2026-04-07

A moist and flavorful pork tenderloin infused with cranberry sauce and orange zest, slow-cooked to perfection for a crowd-pleasing dinner that requires minimal effort. This American-inspired slow-cooker recipe, ready in about 315 minutes, pairs pork tenderloin, cranberry sauce, orange juice for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 320 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 1.5 lbs pork tenderloin
• 1/2 cup (whole berry) cranberry sauce
• 1/4 cup orange juice
• 2 tbsp honey
• 1 tbsp Dijon mustard
• 1 tsp dried thyme
• 1/2 tsp garlic powder
• 1/4 tsp salt
• 1/4 tsp black pepper

The slow cooker we’d leave this in all day → Best Slow Cookers in 2026: Top Picks + Buying Guide

Instructions

1. Step 1: Place the 1.5 lbs pork tenderloin in a 6-quart slow cooker. In a small bowl, whisk 1/2 cup cranberry sauce, 1/4 cup orange juice, 2 tbsp honey, 1 tbsp Dijon mustard, 1 tsp dried thyme, 1/2 tsp garlic powder, 1/4 tsp salt, and 1/4 tsp black pepper until smooth.
2. Step 2: Pour the cranberry sauce mixture evenly over the pork tenderloin, ensuring it's well coated.
3. Step 3: Cover the slow cooker and cook on LOW for 5 hours or HIGH for 2.5 hours, until the pork reaches 145°F (63°C) internally.
4. Step 4: Remove pork, let rest for 5 minutes, slice into 1/2-inch medallions, and serve with the sauce from the slow cooker.