Grilled Cajun-Spiced Shrimp Po' Boy Sandwich

By AislePrompt Test Kitchen · Reviewed by AislePrompt Editorial · ·

Tender shrimp seasoned with bold Cajun spices grilled to perfection, served in a crusty French roll with crisp lettuce and tangy remoulade sauce. This american-inspired sandwiches & wraps ready in about 25 minutes pairs peeled and deveined large shrimp, Cajun seasoning, olive oil for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 420 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 10 min Serves 4 American cuisine 420 cal/serving
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Ingredients

Instructions

  1. Step 1: Toss 1 lb peeled and deveined large shrimp with 2 tbsp olive oil and 2 tbsp Cajun seasoning until evenly coated.
  2. Step 2: Heat a grill pan over medium-high heat and grill shrimp for 2-3 minutes per side until opaque and slightly charred.
  3. Step 3: In a small bowl, combine 1/2 cup mayonnaise, 1 tbsp Dijon mustard, 1 tbsp fresh lemon juice, 1 tsp Worcestershire sauce, 1/2 tsp garlic powder, and 1 tsp hot sauce to create remoulade sauce.
  4. Step 4: Slice 4 French rolls horizontally, lightly toast them on the grill for 1 minute, then spread a generous layer of remoulade sauce on each half.
  5. Step 5: Layer grilled shrimp and 1 cup shredded romaine lettuce inside each roll, then close sandwiches and serve immediately.

Equipment for this recipe

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Frequently asked questions

How long does Grilled Cajun-Spiced Shrimp Po' Boy Sandwich take to make?

Total time is about 25 minutes (15 min prep + 10 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Grilled Cajun-Spiced Shrimp Po' Boy Sandwich?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep cajun seasoning from drying out.

Can I substitute ingredients in Grilled Cajun-Spiced Shrimp Po' Boy Sandwich?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Grilled Cajun-Spiced Shrimp Po' Boy Sandwich for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Grilled Cajun-Spiced Shrimp Po' Boy Sandwich?

American sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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