Mesquite-Grilled Brisket Sandwiches with Smoky BBQ Sauce

By AislePrompt Editorial · Published 2026-06-11 · Updated 2026-06-11

How this recipe was made — this recipe was drafted by AislePrompt's AI-assisted pipeline from technique templates and USDA-sourced nutrition data, and published by AislePrompt Editorial — see how AislePrompt recipes are developed and reviewed.

Thinly sliced mesquite-smoked brisket piled on toasted buns and topped with a homemade smoky barbecue sauce for a hearty sandwich. This American-inspired barbecue recipe, ready in about 500 minutes, pairs beef brisket, kosher salt, black pepper for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 600 calories and feeds 8, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 20 min Cook: 480 min Serves 8 American cuisine 600 cal/serving

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Ingredients

4 lbs beef brisket
2 tbsp kosher salt
1 tbsp black pepper
1 tbsp smoked paprika
2 tsp garlic powder
2 tsp onion powder
3 cups mesquite wood chips
8 buns, toasted
1/2 cup ketchup
1/4 cup apple cider vinegar
2 tbsp molasses
1 tbsp Worcestershire sauce
1 tsp hot sauce
2 tbsp brown sugar

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Instructions

Step 1: Mix 2 tbsp kosher salt, 1 tbsp black pepper, 1 tbsp smoked paprika, 2 tsp garlic powder, and 2 tsp onion powder in a small bowl. Rub this spice blend evenly over the entire 4 lb beef brisket.
Step 2: Soak 3 cups mesquite wood chips in water for 30 minutes. Preheat smoker or grill to 250°F (121°C) and add the soaked wood chips to create smoke.
Step 3: Place brisket fat-side up on the smoker grate and smoke for 6-8 hours until internal temperature reaches 195°F and meat is tender.
Step 4: While brisket smokes, combine 1/2 cup ketchup, 1/4 cup apple cider vinegar, 2 tbsp molasses, 1 tbsp Worcestershire sauce, 1 tsp hot sauce, and 2 tbsp brown sugar in a saucepan. Simmer over medium heat for 10 minutes until sauce thickens and flavors meld.
Step 5: Remove brisket from smoker and let rest for 30 minutes. Slice thinly against the grain.
Step 6: Assemble sandwiches by placing sliced brisket on 8 toasted buns and spooning smoky BBQ sauce over the meat before serving.