Oyster Po’Boy with Spicy Remoulade and Lettuce

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

Crispy fried oysters nestled in a soft French roll with spicy remoulade sauce and fresh lettuce for a classic Southern sandwich. This southern-inspired seafood ready in about 35 minutes pairs shucked Fresh oysters, All-purpose flour, Cornmeal for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 650 calories and feeds 2, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 20 min Cook: 15 min Serves 2 Southern cuisine 650 cal/serving
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Ingredients

Instructions

  1. Step 1: In a shallow bowl, whisk together 1 cup all-purpose flour, 1/2 cup cornmeal, 1 tsp paprika, 1/2 tsp cayenne pepper, and 1 tsp salt.
  2. Step 2: Dip 12 shucked fresh oysters into 1 cup buttermilk, then dredge them in the seasoned flour-cornmeal mixture, coating evenly.
  3. Step 3: Heat 2 cups vegetable oil in a deep skillet over medium-high heat to 350°F; fry oysters in batches for 2-3 minutes until golden brown and crispy, then drain on paper towels.
  4. Step 4: In a small bowl, mix 1/2 cup mayonnaise, 1 tbsp Dijon mustard, 1 tbsp horseradish, 1 tsp hot sauce, 1 tsp lemon juice, and 1/2 tsp garlic powder to make the remoulade sauce.
  5. Step 5: Spread remoulade generously on 2 split French rolls, layer with 1 cup shredded iceberg lettuce and the fried oysters, then serve immediately.

Equipment for this recipe

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Frequently asked questions

How long does Oyster Po’Boy with Spicy Remoulade and Lettuce take to make?

Total time is about 35 minutes (20 min prep + 15 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Oyster Po’Boy with Spicy Remoulade and Lettuce?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep shucked fresh oysters from drying out.

Can I substitute ingredients in Oyster Po’Boy with Spicy Remoulade and Lettuce?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Oyster Po’Boy with Spicy Remoulade and Lettuce for a different number of people?

The recipe is written for 2 servings. Multiply each ingredient by (your serving target / 2). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Oyster Po’Boy with Spicy Remoulade and Lettuce?

Southern seafood like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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