Pan-Seared Salmon with Roasted Brussels Sprouts and Garlic

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

A simple paleo-friendly dish featuring tender salmon fillets seared to perfection paired with caramelized Brussels sprouts roasted with garlic. This mediterranean-inspired paleo (gluten free) ready in about 40 minutes pairs salmon fillets, Brussels sprouts, garlic cloves for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 370 calories and feeds 4, so it slots cleanly into a paleo week and pairs well with roasted root vegetables or a leafy salad. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

★ 4.1 (15 ratings) Prep: 10 min Cook: 30 min Serves 4 Mediterranean cuisine 370 cal/serving
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Ingredients

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Instructions

  1. Step 1: Preheat your oven to 400°F. Toss 1 lb halved Brussels sprouts with 2 tbsp olive oil, 4 minced garlic cloves, 1/2 tsp sea salt, and 1/4 tsp black pepper in a mixing bowl until evenly coated. Spread them on a baking sheet in a single layer and roast for 20-25 minutes until tender and caramelized on the edges.
  2. Step 2: While the Brussels sprouts roast, heat 1 tbsp olive oil in a large skillet over medium-high heat. Pat dry 4 salmon fillets (6 oz each) and season both sides with 1/2 tsp sea salt and 1/4 tsp black pepper. Place fillets skin-side down in the skillet and sear for 4-5 minutes until the skin is crispy and golden.
  3. Step 3: Flip the salmon fillets and cook for an additional 3-4 minutes until the salmon flakes easily with a fork and is opaque throughout.
  4. Step 4: Serve each salmon fillet alongside a generous portion of the garlic roasted Brussels sprouts, garnished with lemon wedges for squeezing over the top.

Frequently asked questions

How long does Pan-Seared Salmon with Roasted Brussels Sprouts and Garlic take to make?

Total time is about 40 minutes (10 min prep + 30 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Pan-Seared Salmon with Roasted Brussels Sprouts and Garlic?

Refrigerate in a covered airtight container for up to 3–4 days (FDA FoodKeeper guideline for cooked fish). Store any fresh salsa or citrus-based garnish in a separate container — it keeps for up to 2 days. Freeze cooked fish (without fresh garnishes) for up to 3 months; thaw overnight in the fridge and reheat gently at 275°F until just warmed through to preserve texture.

Can I substitute ingredients in Pan-Seared Salmon with Roasted Brussels Sprouts and Garlic?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Pan-Seared Salmon with Roasted Brussels Sprouts and Garlic for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

Is Pan-Seared Salmon with Roasted Brussels Sprouts and Garlic paleo?

Yes — this recipe is tagged paleo, gluten free based on its ingredient list. Always cross-check labels for packaged ingredients (sauces, broths, condiments) since formulations vary by brand.

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