Pan-Seared Salmon with Roasted Brussels Sprouts and Orange Glaze

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

Tender pan-seared salmon served alongside caramelized Brussels sprouts drizzled with a bright, tangy orange glaze. This mediterranean-inspired whole30 (gluten free, dairy free) ready in about 40 minutes pairs (6 oz each), skin on salmon fillets, trimmed and halved Brussels sprouts, divided olive oil for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 430 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 10 min Cook: 30 min Serves 4 Mediterranean cuisine 430 cal/serving
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Ingredients

Instructions

  1. Step 1: Preheat oven to 425°F. Toss 1 lb halved Brussels sprouts with 2 tbsp olive oil, 1 tsp sea salt, and 1/2 tsp black pepper. Spread evenly on a baking sheet and roast for 20-25 minutes, stirring halfway, until caramelized and tender.
  2. Step 2: While Brussels sprouts roast, heat a large nonstick skillet over medium-high heat. Season 4 salmon fillets with 1/2 tsp sea salt and 1/2 tsp black pepper. Add 2 tbsp olive oil to the pan and place salmon skin-side down. Cook for 5-6 minutes without moving until skin is crisp.
  3. Step 3: Flip salmon and cook an additional 2-3 minutes until salmon is opaque and flakes easily.
  4. Step 4: In a small saucepan over medium heat, combine 1/3 cup freshly squeezed orange juice, 1 tsp orange zest, 1 minced garlic clove, and 1/4 tsp red pepper flakes. Simmer gently for 5-6 minutes until the mixture thickens slightly into a glaze.
  5. Step 5: Drizzle the orange glaze over the roasted Brussels sprouts and salmon fillets just before serving.

Equipment for this recipe

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Frequently asked questions

How long does Pan-Seared Salmon with Roasted Brussels Sprouts and Orange Glaze take to make?

Total time is about 40 minutes (10 min prep + 30 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Pan-Seared Salmon with Roasted Brussels Sprouts and Orange Glaze?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep divided olive oil from drying out.

Can I substitute ingredients in Pan-Seared Salmon with Roasted Brussels Sprouts and Orange Glaze?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Pan-Seared Salmon with Roasted Brussels Sprouts and Orange Glaze for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

Is Pan-Seared Salmon with Roasted Brussels Sprouts and Orange Glaze gluten free?

Yes — this recipe is tagged gluten free, dairy free, paleo, whole30 based on its ingredient list. Always cross-check labels for packaged ingredients (sauces, broths, condiments) since formulations vary by brand.

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