Sautéed Chicken with Honey Mustard and Roasted Brussels Sprouts

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

Pan-seared and glazed with a honey mustard sauce, served alongside caramelized roasted Brussels sprouts. This American-inspired chicken recipe, ready in about 40 minutes, pairs boneless skinless chicken breasts, olive oil, Brussels sprouts for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 420 calories and feeds 2, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 10 min Cook: 30 min Serves 2 American cuisine 420 cal/serving
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Ingredients

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Instructions

  1. Step 1: Preheat oven to 425°F. Toss 12 oz halved Brussels sprouts with 1 tbsp olive oil, 1/2 tsp salt, and 1/4 tsp black pepper on a baking sheet. Roast for 20 minutes until edges are crispy and caramelized.
  2. Step 2: While Brussels roast, season 2 boneless skinless chicken breasts on both sides with 1/2 tsp salt, 1/4 tsp black pepper, and 1 tsp garlic powder. Heat 2 tbsp olive oil in a large skillet over medium-high heat.
  3. Step 3: Add chicken breasts and sear for 5-6 minutes per side until golden brown and cooked through (internal temperature 165°F). Remove chicken and set aside.
  4. Step 4: In the same skillet, reduce heat to medium-low and whisk together 2 tbsp Dijon mustard, 1 tbsp honey, and 2 tbsp water, scraping up brown bits. Simmer for 2 minutes until sauce thickens and coats the back of a spoon.
  5. Step 5: Return chicken to skillet and spoon honey mustard sauce over the top to glaze. Serve chicken with roasted Brussels sprouts alongside.

Frequently asked questions

How long does Sautéed Chicken with Honey Mustard and Roasted Brussels Sprouts take to make?

Total time is about 40 minutes (10 min prep + 30 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Sautéed Chicken with Honey Mustard and Roasted Brussels Sprouts?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep olive oil from drying out.

Can I substitute ingredients in Sautéed Chicken with Honey Mustard and Roasted Brussels Sprouts?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Sautéed Chicken with Honey Mustard and Roasted Brussels Sprouts for a different number of people?

The recipe is written for 2 servings. Multiply each ingredient by (your serving target / 2). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Sautéed Chicken with Honey Mustard and Roasted Brussels Sprouts?

American chicken like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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