Sheet Pan Mustard-Honey Glazed Salmon with Roasted Brussels Sprouts

By AislePrompt Test Kitchen · Reviewed by AislePrompt Editorial · ·

Oven-roasting fresh salmon fillets with a tangy mustard-honey glaze creates a tender, flavorful entrée paired perfectly with caramelized Brussels sprouts. This american-inspired seafood ready in about 40 minutes pairs 6 oz each salmon fillets, trimmed and halved Brussels sprouts, Dijon mustard for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 320 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 25 min Serves 4 American cuisine 320 cal/serving
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Ingredients

Instructions

  1. Step 1: Preheat oven to 425°F. In a small bowl, whisk together 3 tbsp Dijon mustard, 2 tbsp honey, 1 tbsp lemon juice, and 1 minced garlic clove until smooth and fragrant.
  2. Step 2: On a large rimmed sheet pan, toss 1 lb halved Brussels sprouts with 2 tbsp olive oil, 1/2 tsp salt, and 1/4 tsp black pepper. Spread evenly and roast for 10 minutes.
  3. Step 3: Remove pan from oven, push Brussels sprouts to one side. Place 4 salmon fillets skin-side down on the empty side. Brush each fillet generously with the mustard-honey glaze.
  4. Step 4: Drizzle remaining 1 tbsp olive oil and sprinkle 1/2 tsp salt and 1/4 tsp black pepper over salmon and Brussels sprouts. Roast everything together for an additional 12-15 minutes until salmon flakes easily and Brussels sprouts are caramelized.
  5. Step 5: Remove from oven and let rest 3 minutes before serving to allow flavors to meld.

Equipment for this recipe

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Frequently asked questions

How long does Sheet Pan Mustard-Honey Glazed Salmon with Roasted Brussels Sprouts take to make?

Total time is about 40 minutes (15 min prep + 25 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Sheet Pan Mustard-Honey Glazed Salmon with Roasted Brussels Sprouts?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep 6 oz each salmon fillets from drying out.

Can I substitute ingredients in Sheet Pan Mustard-Honey Glazed Salmon with Roasted Brussels Sprouts?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Sheet Pan Mustard-Honey Glazed Salmon with Roasted Brussels Sprouts for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Sheet Pan Mustard-Honey Glazed Salmon with Roasted Brussels Sprouts?

American seafood like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.