Slow-Cooked Beef Brisket with St. Louis BBQ Sauce

By AislePrompt Editorial · Published 2026-06-09 · Updated 2026-06-09

How this recipe was made — this recipe was drafted by AislePrompt's AI-assisted pipeline from technique templates and USDA-sourced nutrition data, and published by AislePrompt Editorial — see how AislePrompt recipes are drafted and published.

Tender beef brisket slow-cooked and glazed with a smoky, tangy St. Louis-style barbecue sauce perfect for a weekend feast. This American-inspired barbecue recipe, ready in about 290 minutes, pairs beef brisket, salt, black pepper for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 550 calories and feeds 6, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 20 min Cook: 270 min Serves 6 American cuisine 550 cal/serving

Build a week of meals around this recipe → Shop this recipe on Instacart → Shop equipment ↓

Ingredients

3 pounds beef brisket
1 tbsp salt
1 tbsp black pepper
2 tsp smoked paprika
1 tsp garlic powder
1 tsp onion powder
2 tbsp olive oil
1/4 cup yellow mustard
1/4 cup apple cider vinegar
1/2 cup ketchup
2 tbsp brown sugar
1 tbsp Worcestershire sauce
1 tsp liquid smoke
1 tsp chili powder

The grilling tools we’d reach for here → Best Grilling Tools and BBQ Gadgets for 2026: Top Picks + Buying Guide

Affiliate disclosure: AislePrompt may earn a commission on qualifying purchases made through Amazon links, at no additional cost to you. See our policy →

Equipment for this recipe

Tools this recipe's steps call for, with a link to each on Amazon.

More Cookware & pots → Shop all kitchen tools →

Instructions

Step 1: Preheat oven to 275°F. Rub 3 pounds beef brisket evenly with 1 tablespoon salt, 1 tablespoon black pepper, 2 teaspoons smoked paprika, 1 teaspoon garlic powder, and 1 teaspoon onion powder to create a spice crust.
Step 2: Heat 2 tablespoons olive oil in a large oven-safe skillet over medium-high heat. Sear the brisket for 3-4 minutes per side until a deep brown crust forms, then remove from heat.
Step 3: In a bowl, whisk together 1/4 cup yellow mustard, 1/4 cup apple cider vinegar, 1/2 cup ketchup, 2 tablespoons brown sugar, 1 tablespoon Worcestershire sauce, 1 teaspoon liquid smoke, and 1 teaspoon chili powder until smooth and well combined.
Step 4: Brush the entire surface of the seared brisket with half of the barbecue sauce. Cover the skillet tightly with foil and roast in the preheated oven for 4 hours, basting with remaining sauce every hour.
Step 5: After 4 hours, remove foil and roast uncovered for an additional 30 minutes to caramelize the glaze, until the sauce thickens and the edges are slightly crispy.
Step 6: Let the brisket rest for 15 minutes before slicing thinly against the grain. Serve with extra BBQ sauce on the side.