Slow-Roasted Beef Brisket with Smoky Chipotle Glaze

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

Tender slow-roasted beef brisket coated with a smoky chipotle glaze, perfect for a hearty family dinner. This mexican-inspired street food ready in about 260 minutes pairs beef brisket, chipotle powder, smoked paprika for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 450 calories and feeds 6, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

★ 4.4 (8 ratings) Prep: 20 min Cook: 240 min Serves 6 Mexican cuisine 450 cal/serving
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Ingredients

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Instructions

  1. Step 1: Preheat oven to 275°F. In a small bowl, combine 2 teaspoons chipotle powder, 1 teaspoon smoked paprika, 1 teaspoon garlic powder, 2 tablespoons brown sugar, 2 teaspoons kosher salt, and 1 teaspoon ground black pepper. Rub this spice mixture evenly over the entire surface of the 3 pounds beef brisket.
  2. Step 2: Heat 2 tablespoons olive oil in a large oven-safe skillet over medium-high heat. Sear the brisket for 4 minutes per side until a dark crust forms, then transfer skillet to the oven and roast uncovered for 3 hours, checking occasionally.
  3. Step 3: After 3 hours, mix 1/4 cup apple cider vinegar with 1/2 cup water and pour over the brisket. Continue roasting for an additional 1 hour, basting every 20 minutes, until the meat is fork-tender and internal temperature reaches 195°F.
  4. Step 4: Remove brisket from oven and let rest for 20 minutes. Slice against the grain and sprinkle 1/4 cup chopped fresh cilantro before serving.

Frequently asked questions

How long does Slow-Roasted Beef Brisket with Smoky Chipotle Glaze take to make?

Total time is about 260 minutes (20 min prep + 240 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Slow-Roasted Beef Brisket with Smoky Chipotle Glaze?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep beef brisket from drying out.

Can I substitute ingredients in Slow-Roasted Beef Brisket with Smoky Chipotle Glaze?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Slow-Roasted Beef Brisket with Smoky Chipotle Glaze for a different number of people?

The recipe is written for 6 servings. Multiply each ingredient by (your serving target / 6). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Slow-Roasted Beef Brisket with Smoky Chipotle Glaze?

Mexican street food like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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