Slow-Roasted Cajun-Spiced Beef Brisket

By AislePrompt Editorial · Published 2026-05-30 · Updated 2026-05-30

How this recipe was made — this recipe was drafted by AislePrompt's AI-assisted pipeline from technique templates and USDA-sourced nutrition data, and published by AislePrompt Editorial — see how AislePrompt recipes are drafted and published.

Tender, slow-roasted beef brisket infused with a smoky Cajun spice blend, perfect for a comforting meal. This Southern American-inspired beef recipe, ready in about 340 minutes, pairs beef brisket, olive oil, smoked paprika for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 450 calories and feeds 6, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 40 min Cook: 300 min Serves 6 Southern American cuisine 450 cal/serving

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Ingredients

3 lbs beef brisket
2 tbsp olive oil
1 tbsp smoked paprika
1 tsp cayenne pepper
1 tsp garlic powder
1 tsp onion powder
1 tsp dried thyme
1 1/2 tsp salt
1 tsp black pepper
1 cup beef broth

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Instructions

Step 1: Preheat the oven to 275°F. Mix 1 tbsp smoked paprika, 1 tsp cayenne pepper, 1 tsp garlic powder, 1 tsp onion powder, 1 tsp dried thyme, 1 1/2 tsp salt, and 1 tsp black pepper in a small bowl to create the Cajun spice blend.
Step 2: Rub 3 lbs beef brisket evenly with 2 tbsp olive oil, then coat it thoroughly with the Cajun spice blend. Let rest at room temperature for 30 minutes.
Step 3: Place the seasoned brisket fat side up in a roasting pan. Pour 1 cup beef broth into the pan to keep the meat moist during cooking.
Step 4: Cover the roasting pan tightly with foil and roast in the preheated oven for 4 to 5 hours until the brisket is fork-tender and reaches an internal temperature of 195°F.
Step 5: Remove the foil and roast uncovered for an additional 15 minutes to develop a crusty exterior. Let rest for 20 minutes before slicing against the grain and serving.