Spiced Mezcal Negroni with Blood Orange

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

A smoky mezcal variation of the classic Negroni, enriched with blood orange juice and a touch of warming spices for depth. This Italian-inspired recipe, ready in about 5 minutes, brings together mezcal, Campari, sweet vermouth for a refreshing, crowd-pleasing drink — a bright, easy pour for parties, gatherings, or any warm-weather afternoon when you want something festive without alcohol-only options. Each serving lands at about 190 calories and feeds 1, so it works for entertaining, brunch, or a non-alcoholic option at the bar cart. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 5 min Serves 1 Italian cuisine 190 cal/serving
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Ingredients

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Instructions

  1. Step 1: Fill a mixing glass with ice cubes to chill for 1 minute.
  2. Step 2: Add 1 oz mezcal, 1 oz Campari, 1 oz sweet vermouth, 0.5 oz fresh blood orange juice, and a pinch of ground star anise to the mixing glass.
  3. Step 3: Stir gently for 30 seconds until the mixture is well chilled and slightly diluted.
  4. Step 4: Strain into a rocks glass over a large ice cube.
  5. Step 5: Express the oils of 1 orange peel over the drink, then use it as garnish to add a bright citrus aroma.

Frequently asked questions

How long does Spiced Mezcal Negroni with Blood Orange take to make?

Total time is about 5 minutes (5 min prep + 0 min cook). Most home bartenders find this fits a single afternoon; scale up the batch for parties or pitchers.

How do I store leftover Spiced Mezcal Negroni with Blood Orange?

Refrigerate any leftover spiced mezcal negroni with blood orange in a sealed pitcher or jar for up to 3–4 days. Do not reheat — drinks are served chilled. If the recipe uses sparkling water or fresh herbs, hold those back and add fresh just before pouring so the drink stays bright and fizzy.

Can I substitute ingredients in Spiced Mezcal Negroni with Blood Orange?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Spiced Mezcal Negroni with Blood Orange for a different number of people?

The recipe is written for 1 servings. Multiply each ingredient by (your serving target / 1). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Spiced Mezcal Negroni with Blood Orange?

Italian cocktails & drinks like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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