Blood Orange Mezcal Negroni

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

A smoky mezcal twist on the classic Negroni with bright blood orange and balanced bittersweet flavors. This cocktails & drinks ready in about 5 minutes brings together mezcal, sweet vermouth, Campari for a refreshing, crowd-pleasing drink — a bright, easy pour for parties, gatherings, or any warm-weather afternoon when you want something festive without alcohol-only options. Each serving lands at about 180 calories and feeds 1, so it works for entertaining, brunch, or a non-alcoholic option at the bar cart. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 5 min Serves 1 Cocktails & Drinks cuisine 180 cal/serving
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Ingredients

Equipment for this recipe

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Instructions

  1. Step 1: Fill a mixing glass with ice cubes to the brim.
  2. Step 2: Pour in 1 oz mezcal, 1 oz sweet vermouth, 1 oz Campari, and 1/2 oz fresh blood orange juice.
  3. Step 3: Stir gently with a bar spoon for 30 seconds to chill and dilute slightly.
  4. Step 4: Strain into a rocks glass over one large clear ice cube.
  5. Step 5: Garnish with a blood orange wheel rested on the rim, expressing the oils over the surface before placing.

Frequently asked questions

How long does Blood Orange Mezcal Negroni take to make?

Total time is about 5 minutes (5 min prep + 0 min cook). Most home bartenders find this fits a single afternoon; scale up the batch for parties or pitchers.

How do I store leftover Blood Orange Mezcal Negroni?

Refrigerate any leftover blood orange mezcal negroni in a sealed pitcher or jar for up to 3–4 days. Do not reheat — drinks are served chilled. If the recipe uses sparkling water or fresh herbs, hold those back and add fresh just before pouring so the drink stays bright and fizzy.

Can I substitute ingredients in Blood Orange Mezcal Negroni?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Blood Orange Mezcal Negroni for a different number of people?

The recipe is written for 1 servings. Multiply each ingredient by (your serving target / 1). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Blood Orange Mezcal Negroni?

Cocktails & Drinks cocktails & drinks like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.