Griddled Rye Bread Sandwich with Pastrami, Swiss, and Pickled Onions

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

A classic Brooklyn diner-inspired sandwich featuring layers of peppery pastrami, melted Swiss cheese, and tangy pickled red onions on griddled rye bread. This american-inspired sandwiches & wraps ready in about 50 minutes pairs rye bread slices, sliced pastrami, Swiss cheese slices for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 550 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 40 min Cook: 10 min Serves 4 American cuisine 550 cal/serving
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Ingredients

Instructions

  1. Step 1: Combine 1/2 cup white vinegar, 1/2 cup water, 1 tbsp sugar, and 1/2 tsp black pepper in a small saucepan. Bring to a simmer over medium heat, stirring until sugar dissolves. Remove from heat and add 1 medium thinly sliced red onion. Let cool and marinate at least 30 minutes.
  2. Step 2: Spread 4 tbsp softened unsalted butter evenly on one side of each of 8 rye bread slices.
  3. Step 3: Heat a large skillet or griddle over medium heat. Place 4 bread slices butter-side down. Spread 1 tbsp Dijon mustard on the unbuttered side of each slice.
  4. Step 4: Layer 3 oz sliced pastrami, 1 1/2 slices Swiss cheese, and a generous amount of pickled red onions drained from marinade on each. Top with remaining bread slices, butter-side up.
  5. Step 5: Grill sandwiches for 4-5 minutes per side until bread is golden brown and cheese melts, pressing gently with a spatula. Slice in half and serve warm.

Equipment for this recipe

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Frequently asked questions

How long does Griddled Rye Bread Sandwich with Pastrami, Swiss, and Pickled Onions take to make?

Total time is about 50 minutes (40 min prep + 10 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Griddled Rye Bread Sandwich with Pastrami, Swiss, and Pickled Onions?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep rye bread slices from drying out.

Can I substitute ingredients in Griddled Rye Bread Sandwich with Pastrami, Swiss, and Pickled Onions?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Griddled Rye Bread Sandwich with Pastrami, Swiss, and Pickled Onions for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Griddled Rye Bread Sandwich with Pastrami, Swiss, and Pickled Onions?

American sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.