Grilled Cajun-Spiced Catfish with Lemon Butter Sauce

By AislePrompt Editorial · Published 2026-05-18 · Updated 2026-05-18

How this recipe was made — this recipe was drafted by AislePrompt's AI-assisted pipeline from technique templates and USDA-sourced nutrition data, and published by AislePrompt Editorial — see how AislePrompt recipes are drafted and published.

A smoky grilled catfish fillet seasoned with Cajun spices, served with a zesty lemon butter sauce that enhances its fresh flavor. This Southern American-inspired seafood recipe, ready in about 22 minutes, pairs catfish fillets, Cajun seasoning, olive oil for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 320 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 10 min Cook: 12 min Serves 4 Southern American cuisine 320 cal/serving

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Ingredients

4 pieces, about 6 oz each catfish fillets
2 tbsp Cajun seasoning
2 tbsp olive oil
4 tbsp unsalted butter
3 tbsp fresh lemon juice
3, minced garlic cloves
2 tbsp, chopped fresh parsley
1 tsp salt
1/2 tsp black pepper

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Instructions

Step 1: Preheat your grill or grill pan to medium-high heat (about 400°F). Rub 4 catfish fillets evenly with 2 tbsp olive oil, 2 tbsp Cajun seasoning, 1 tsp salt, and 1/2 tsp black pepper, coating all sides thoroughly.
Step 2: Place the seasoned catfish fillets on the grill and cook for 4-5 minutes per side until opaque and flakey, with light grill marks.
Step 3: While the fish cooks, melt 4 tbsp unsalted butter in a small saucepan over medium heat. Add 3 minced garlic cloves and sauté for 1-2 minutes until fragrant but not browned.
Step 4: Stir in 3 tbsp fresh lemon juice and 2 tbsp chopped fresh parsley into the butter sauce, cooking for another 30 seconds until combined and aromatic.
Step 5: Remove catfish from the grill, drizzle with the lemon butter sauce, and serve immediately with your choice of sides.