Pan-Seared Pork Tenderloin with Roasted Brussels Sprouts

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

Tender pork tenderloin pan-seared to perfection and paired with caramelized roasted Brussels sprouts for a wholesome Whole30 meal. This american-inspired pork (whole30, gluten free) ready in about 45 minutes pairs pork tenderloin, Brussels sprouts, halved, extra virgin olive oil for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 350 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 10 min Cook: 35 min Serves 4 American cuisine 350 cal/serving
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Ingredients

Instructions

  1. Step 1: Preheat oven to 425°F. Toss 1 pound halved Brussels sprouts with 2 tablespoons extra virgin olive oil, 1 teaspoon sea salt, and 1/2 teaspoon black pepper. Spread on a baking sheet and roast for 20-25 minutes until golden brown and crisp on edges.
  2. Step 2: While sprouts roast, pat 1 pound pork tenderloin dry and season with 1/2 teaspoon sea salt, 1/2 teaspoon black pepper, and 1/2 teaspoon garlic powder.
  3. Step 3: Heat 2 tablespoons extra virgin olive oil in a large skillet over medium-high heat. Add the pork tenderloin and sear for 4-5 minutes on each side until well browned.
  4. Step 4: Reduce heat to medium, cover skillet, and cook pork for an additional 8-10 minutes, turning occasionally, until internal temperature reaches 145°F.
  5. Step 5: Remove pork from skillet and let rest for 5 minutes before slicing. Serve sliced pork alongside the roasted Brussels sprouts.

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Frequently asked questions

How long does Pan-Seared Pork Tenderloin with Roasted Brussels Sprouts take to make?

Total time is about 45 minutes (10 min prep + 35 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Pan-Seared Pork Tenderloin with Roasted Brussels Sprouts?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep pork tenderloin from drying out.

Can I substitute ingredients in Pan-Seared Pork Tenderloin with Roasted Brussels Sprouts?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Pan-Seared Pork Tenderloin with Roasted Brussels Sprouts for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

Is Pan-Seared Pork Tenderloin with Roasted Brussels Sprouts whole30?

Yes — this recipe is tagged whole30, gluten free, dairy free, paleo based on its ingredient list. Always cross-check labels for packaged ingredients (sauces, broths, condiments) since formulations vary by brand.

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