Sheet Pan Cajun-Spiced Catfish with Roasted Southern Vegetables

By Lauren Mitchell, Test Kitchen Director · Reviewed by AislePrompt Editorial · Published 2026-07-15 · Updated 2026-07-15

A hearty sheet pan dinner featuring Cajun-spiced catfish fillets roasted alongside a medley of traditional Southern vegetables. This southern american-inspired seafood ready in about 39 minutes pairs fillets (6 oz each) catfish fillets, olive oil, Cajun seasoning for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 320 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 4 fillets (6 oz each) catfish fillets
• 3 tbsp olive oil
• 2 tbsp Cajun seasoning
• 1 tsp smoked paprika
• 1 tsp garlic powder
• 1 medium, sliced into 1/4-inch rounds yellow squash
• 1 medium, sliced into 1/4-inch rounds zucchini
• 1 large, cut into 1-inch chunks red bell pepper
• 1 medium, sliced into thin wedges red onion
• 1, thinly sliced lemon
• 2 tbsp, chopped fresh parsley
• 1 tsp salt
• 1/2 tsp black pepper

Instructions

1. Step 1: Preheat the oven to 425°F. In a large bowl, toss the 1 sliced yellow squash, 1 sliced zucchini, 1 large chopped red bell pepper, and 1 sliced red onion with 2 tbsp olive oil, 1 tsp salt, and 1/2 tsp black pepper until evenly coated.
2. Step 2: Spread the vegetables evenly on a large sheet pan and roast for 12 minutes until they begin to soften and caramelize at the edges.
3. Step 3: While the vegetables roast, pat dry 4 catfish fillets and rub them evenly with 2 tbsp Cajun seasoning, 1 tsp smoked paprika, and 1 tsp garlic powder.
4. Step 4: Remove the sheet pan from the oven and nestle the seasoned catfish fillets among the vegetables. Drizzle the remaining 1 tbsp olive oil over the fish and vegetables, and arrange 1 thinly sliced lemon over the catfish.
5. Step 5: Roast everything together for an additional 10-12 minutes until the catfish is opaque and flakes easily with a fork.
6. Step 6: Remove from the oven and sprinkle 2 tbsp chopped fresh parsley over the dish before serving.