Slow-Roasted Beef Brisket with Lexington Bourbon Barbecue Sauce

By AislePrompt Editorial · Published 2026-07-01 · Updated 2026-07-01

How this recipe was made — this recipe was drafted by AislePrompt's AI-assisted pipeline from technique templates and USDA-sourced nutrition data, and published by AislePrompt Editorial — see how AislePrompt recipes are drafted and published.

Juicy beef brisket slow-roasted until tender, served with a tangy homemade barbecue sauce infused with Kentucky bourbon and a hint of smoky paprika. This American Southern-inspired beef recipe, ready in about 320 minutes, pairs beef brisket, kosher salt, black pepper for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 600 calories and feeds 6, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 20 min Cook: 300 min Serves 6 American Southern cuisine 600 cal/serving

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Ingredients

4 lbs beef brisket
2 tbsp kosher salt
1 tbsp black pepper
1 tbsp smoked paprika
1 tsp garlic powder
1 tsp onion powder
2 tbsp olive oil
1/4 cup bourbon whiskey
1 cup ketchup
1/4 cup apple cider vinegar
2 tbsp brown sugar
1 tbsp Worcestershire sauce
1 tsp dry mustard powder
1 tsp hot sauce

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Instructions

Step 1: Preheat oven to 275°F. Mix 2 tbsp kosher salt, 1 tbsp black pepper, 1 tbsp smoked paprika, 1 tsp garlic powder, and 1 tsp onion powder in a bowl. Rub this spice blend evenly over 4 lbs beef brisket.
Step 2: Heat 2 tbsp olive oil in a large oven-safe pan over medium-high heat. Sear the brisket for 4-5 minutes per side until deeply browned. Transfer pan with brisket to the oven and roast uncovered for 4-5 hours until fork-tender.
Step 3: While brisket roasts, combine 1/4 cup bourbon whiskey, 1 cup ketchup, 1/4 cup apple cider vinegar, 2 tbsp brown sugar, 1 tbsp Worcestershire sauce, 1 tsp dry mustard powder, and 1 tsp hot sauce in a saucepan. Simmer over medium heat for 10 minutes until thickened and glossy.
Step 4: Remove brisket from oven and let rest 20 minutes. Slice against the grain and serve with warm bourbon barbecue sauce drizzled over the top.