Spiced Cajun Po'Boy Sandwich with Fried Catfish

By AislePrompt Editorial · Published 2026-05-23 · Updated 2026-05-23

A classic New Orleans po'boy sandwich with crispy fried catfish, dressed with a spicy remoulade and fresh lettuce on a French roll. This Creole-inspired sandwich and wrap recipe, ready in about 40 minutes, pairs catfish fillets, cornmeal, all-purpose flour for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 600 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 4 pieces (4 oz each) catfish fillets
• 1 cup cornmeal
• 1/2 cup all-purpose flour
• 2 tbsp Cajun seasoning
• 1 1/2 cups buttermilk
• 4 cups vegetable oil for frying
• 4 French rolls
• 1/2 cup mayonnaise
• 2 tbsp Dijon mustard
• 1 tbsp hot sauce
• 1/2 tsp garlic powder
• 1/2 tsp paprika
• 8 lettuce leaves
• 1 large tomato, sliced
• 1/4 cup pickles, sliced

The Dutch oven we’d braise this in → Best Dutch Ovens for 2026: Top Picks + Buying Guide

Instructions

1. Step 1: In a shallow bowl, whisk together 1/2 cup all-purpose flour, 1 cup cornmeal, and 2 tbsp Cajun seasoning. In a separate bowl, pour 1 1/2 cups buttermilk.
2. Step 2: Dip each 4 catfish fillets first into the buttermilk, then dredge thoroughly in the cornmeal-flour mixture until well coated.
3. Step 3: Heat 4 cups vegetable oil in a deep skillet or Dutch oven to 350°F. Fry the coated catfish fillets in batches for 4-5 minutes per side until golden brown and cooked through. Drain on paper towels.
4. Step 4: In a small bowl, mix 1/2 cup mayonnaise, 2 tbsp Dijon mustard, 1 tbsp hot sauce, 1/2 tsp garlic powder, and 1/2 tsp paprika to make a spicy remoulade sauce.
5. Step 5: Slice 4 French rolls lengthwise without cutting all the way through. Spread a generous 2 tbsp of remoulade sauce on each roll.
6. Step 6: Layer 2 leaves of lettuce, 2-3 slices of tomato, fried catfish fillets, and 1 tbsp sliced pickles on each sandwich. Close sandwiches and serve immediately.