Cajun-Spiced Salmon with Shrimp and Creamy Garlic Sauce

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

A one-pan dinner combining wild-caught salmon and shrimp coated in bold Cajun spices, simmered in a rich creamy garlic sauce for a satisfying low-carb meal. This american-inspired seafood (keto, low carb) ready in about 35 minutes blends large, peeled and deveined shrimp, cajun seasoning, unsalted butter into a versatile sauce that lifts everything from grain bowls and roasted vegetables to grilled proteins — a small-batch staple worth keeping in the fridge. Each serving lands at about 520 calories and feeds 4, so a small batch covers several meals across the week without taking over the fridge. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 20 min Serves 4 American cuisine 520 cal/serving
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Ingredients

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Instructions

  1. Step 1: Pat dry 4 skinless salmon fillets and 12 large peeled shrimp. Sprinkle 2 tbsp Cajun seasoning evenly over both sides of the salmon and shrimp.
  2. Step 2: Heat 3 tbsp unsalted butter in a large skillet over medium-high heat until melted and foaming. Add the salmon fillets and cook for 4 minutes per side until nicely browned and cooked through. Remove salmon and set aside.
  3. Step 3: In the same skillet, add 4 minced garlic cloves and sauté for 30 seconds until fragrant. Add 12 shrimp and cook for 2-3 minutes per side until pink and opaque.
  4. Step 4: Reduce heat to medium-low and pour in 1 cup heavy cream, stirring in 1/4 cup grated parmesan cheese until melted and the sauce thickens slightly, about 3-4 minutes.
  5. Step 5: Return the salmon fillets to the skillet, spooning sauce over the top. Season with 1 tsp salt and 1/2 tsp black pepper. Garnish with 2 tbsp chopped fresh parsley before serving.

Frequently asked questions

How long does Cajun-Spiced Salmon with Shrimp and Creamy Garlic Sauce take to make?

Total time is about 35 minutes (15 min prep + 20 min cook). A small batch typically covers several meals in the week — store as the recipe directs.

How do I store leftover Cajun-Spiced Salmon with Shrimp and Creamy Garlic Sauce?

Transfer to an airtight jar and refrigerate for up to 5–7 days. Most sauces freeze well for up to 2 months — portion into small containers or freezer bags so you can thaw only what you need. Stir before serving; cream- or yogurt-based sauces may separate on standing.

Can I substitute ingredients in Cajun-Spiced Salmon with Shrimp and Creamy Garlic Sauce?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Cajun-Spiced Salmon with Shrimp and Creamy Garlic Sauce for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

Is Cajun-Spiced Salmon with Shrimp and Creamy Garlic Sauce keto?

Yes — this recipe is tagged keto, low carb based on its ingredient list. Always cross-check labels for packaged ingredients (sauces, broths, condiments) since formulations vary by brand.