Creole-Spiced Shrimp Po’Boy Sandwich

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

A classic New Orleans sandwich featuring crispy Creole-seasoned shrimp tucked into a crusty French roll with tangy remoulade. This cajun-inspired sandwiches & wraps ready in about 30 minutes pairs peeled and deveined medium shrimp, Creole seasoning, all-purpose flour for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 560 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 15 min Serves 4 Cajun cuisine 560 cal/serving
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Ingredients

Instructions

  1. Step 1: In a medium bowl, toss 1 lb peeled and deveined medium shrimp with 2 tbsp Creole seasoning until evenly coated.
  2. Step 2: Pour 1 cup buttermilk into a shallow dish. Place 1 cup all-purpose flour in another shallow dish. Dip each seasoned shrimp first into the buttermilk, then dredge in flour, shaking off excess.
  3. Step 3: Heat 4 cups vegetable oil in a deep skillet or pot over medium-high heat to 350°F. Fry shrimp in batches for 2-3 minutes until golden brown and crispy. Drain on paper towels.
  4. Step 4: In a small bowl, whisk together 1/2 cup mayonnaise, 1 tbsp Dijon mustard, 1 tsp prepared horseradish, 1 tbsp lemon juice, 1 tsp Worcestershire sauce, and 1/2 tsp garlic powder until smooth to make remoulade sauce.
  5. Step 5: Split 4 French bread rolls lengthwise, toast lightly if desired. Spread remoulade sauce evenly on both sides of each roll.
  6. Step 6: Layer each sandwich with 1/4 cup shredded lettuce, 1/4 cup sliced tomatoes, 1/8 cup sliced pickles, and a generous handful of fried shrimp. Serve immediately.

Equipment for this recipe

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Frequently asked questions

How long does Creole-Spiced Shrimp Po’Boy Sandwich take to make?

Total time is about 30 minutes (15 min prep + 15 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Creole-Spiced Shrimp Po’Boy Sandwich?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep creole seasoning from drying out.

Can I substitute ingredients in Creole-Spiced Shrimp Po’Boy Sandwich?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Creole-Spiced Shrimp Po’Boy Sandwich for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Creole-Spiced Shrimp Po’Boy Sandwich?

Cajun sandwiches & wraps like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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