One-Pot Chicken Pot Pie Casserole

By AislePrompt Editorial · Published 2026-07-06 · Updated 2026-07-06

A comforting and hearty chicken pot pie casserole that combines tender chicken, vegetables, and a creamy sauce all in one dish. This American chicken recipe, ready in about 45 minutes, layers boneless skinless chicken breasts, unsalted butter, and all-purpose flour into a dessert worth slowing down for — great for weekend baking, holiday tables, or any time you want a sweet payoff at the end of a meal. Each serving lands at about 420 calories and feeds 4, so it slots into a weekend bake or a special-occasion dessert tray. Tap "Add this recipe to your weekly plan" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 1 lb boneless skinless chicken breasts
• 1 cup frozen mixed vegetables (carrots, peas, corn)
• 3 tbsp unsalted butter
• 3 tbsp all-purpose flour
• 2 cups chicken broth
• 1 cup milk
• 1 tsp salt
• 1/2 tsp black pepper
• 1/2 tsp dried thyme
• 1 can (about 16 oz) pre-made biscuit dough

The 9x13 baking dish we’d bake this in → Best Bakeware for 2026: Top Picks + Buying Guide

Instructions

1. Step 1: Preheat oven to 375°F. Dice 1 lb boneless skinless chicken breasts into 1-inch cubes. Melt 3 tbsp unsalted butter in a large oven-safe skillet over medium heat, then add the chicken cubes and cook for 5-6 minutes until no longer pink and lightly golden.
2. Step 2: Sprinkle 3 tbsp all-purpose flour over the chicken and stir to coat, cooking for 1 minute to eliminate raw flour taste. Gradually whisk in 2 cups chicken broth and 1 cup milk, stirring constantly until the sauce thickens and coats the back of a spoon, about 4-5 minutes.
3. Step 3: Stir in 1 cup frozen mixed vegetables, 1 tsp salt, 1/2 tsp black pepper, and 1/2 tsp dried thyme. Simmer the filling for 3 minutes until the vegetables are warmed through.
4. Step 4: Remove skillet from heat. Arrange biscuit dough pieces evenly on top of the filling. Bake uncovered for 20-25 minutes until biscuits are golden brown and cooked through. Let cool 5 minutes before serving.