Sheet Pan Cajun-Spiced Catfish with Roasted Sweet Potatoes and Bell Peppers

By Lauren Mitchell, Test Kitchen Director · Reviewed by AislePrompt Editorial · Published 2026-06-17 · Updated 2026-06-17

This one-pan dish features tender catfish fillets dusted with Cajun spices and roasted alongside sweet potatoes and bell peppers for a flavorful, easy meal. This southern-inspired seafood ready in about 45 minutes pairs (6 oz each) catfish fillets, olive oil, Cajun seasoning for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 360 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 4 pieces (6 oz each) catfish fillets
• 2 medium (about 1 lb), peeled and cut into 1-inch cubes sweet potatoes
• 1 large, cut into 1-inch strips red bell pepper
• 1 large, cut into 1-inch strips yellow bell pepper
• 4 tbsp olive oil
• 2 tbsp Cajun seasoning
• 1 tsp garlic powder
• 1 tsp smoked paprika
• 1 1/2 tsp, divided salt
• 1/2 tsp, divided black pepper
• 2 tbsp fresh lemon juice
• 2 tbsp chopped, for garnish fresh parsley

Instructions

1. Step 1: Preheat oven to 425°F. In a large bowl, toss 2 peeled and cubed medium sweet potatoes with 2 tbsp olive oil, 1 tbsp Cajun seasoning, 1/2 tsp salt, and 1/4 tsp black pepper until evenly coated. Spread on a rimmed baking sheet in a single layer.
2. Step 2: Roast the sweet potatoes for 15 minutes. Meanwhile, in the same bowl, combine 4 catfish fillets with 2 tbsp olive oil, 1 tbsp Cajun seasoning, 1 tsp garlic powder, 1 tsp smoked paprika, 1 tsp salt, and 1/4 tsp black pepper. Rub the seasoning evenly on both sides of the fish.
3. Step 3: After 15 minutes, remove the baking sheet from the oven and toss the sweet potatoes. Add 1 large red bell pepper and 1 large yellow bell pepper, both cut into strips, tossing them with 1 tbsp olive oil and a pinch of salt.
4. Step 4: Place the seasoned catfish fillets on top of the vegetables and sweet potatoes. Return to the oven and roast for an additional 12-15 minutes until the fish flakes easily with a fork and the vegetables are tender.
5. Step 5: Remove from oven and drizzle 2 tbsp fresh lemon juice over the fish and vegetables. Garnish with 2 tbsp chopped fresh parsley before serving.