Sheet Pan Cajun-Spiced Catfish with Roasted Veggies

By AislePrompt Editorial · Published 2026-06-25 · Updated 2026-06-25

A bold Cajun-seasoned catfish baked alongside a medley of colorful vegetables, delivering a hearty and flavorful meal with minimal cleanup. This Southern-inspired seafood recipe, ready in about 28 minutes, pairs catfish fillets, olive oil, smoked paprika for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 280 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 4 fillets (6 oz each) catfish fillets
• 3 tbsp olive oil
• 2 tsp smoked paprika
• 1/2 tsp cayenne pepper
• 1 tsp garlic powder
• 1 tsp onion powder
• 1 tsp dried thyme
• 1 tsp salt
• 1/2 tsp black pepper
• 1 large, sliced into 1/2-inch strips red bell pepper
• 1 medium, sliced into 1/2-inch rounds zucchini
• 1 medium, sliced into 1/2-inch rounds yellow squash
• 1, cut into wedges lemon

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Instructions

1. Step 1: Preheat oven to 425°F (220°C). In a small bowl, mix 3 tbsp olive oil, 2 tsp smoked paprika, 1/2 tsp cayenne pepper, 1 tsp garlic powder, 1 tsp onion powder, 1 tsp dried thyme, 1 tsp salt, and 1/2 tsp black pepper to create the Cajun spice blend.
2. Step 2: On a large rimmed baking sheet, toss 1 large sliced red bell pepper, 1 medium sliced zucchini, and 1 medium sliced yellow squash with half of the Cajun spice blend and 1 tbsp olive oil, spreading them evenly.
3. Step 3: Arrange 4 catfish fillets on the baking sheet among the vegetables. Brush the remaining Cajun spice blend over the catfish fillets evenly.
4. Step 4: Roast in the oven for 15-18 minutes until the catfish flakes easily with a fork and the vegetables are tender and lightly caramelized.
5. Step 5: Serve the catfish and roasted vegetables with 1 lemon cut into wedges for squeezing over the top.