Sheet Pan Herb-Crusted Pork Tenderloin with Roasted Brussels Sprouts

By , Test Kitchen Director · Reviewed by AislePrompt Editorial · ·

Juicy pork tenderloin coated in fresh herbs roasted alongside Brussels sprouts for a simple Whole30 dinner on one pan. This pork (whole30, gluten free) ready in about 45 minutes pairs (680g) pork tenderloin, (450g) Brussels sprouts, halved, olive oil for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 380 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 30 min Serves 4 380 cal/serving
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Ingredients

Instructions

  1. Step 1: Preheat oven to 400°F. In a small bowl, combine 3 tbsp olive oil, 1 tbsp finely chopped fresh rosemary, 1 tbsp fresh thyme leaves, 3 minced garlic cloves, 1 1/2 tsp sea salt, 1 tsp black pepper, and 1 tsp lemon zest to make a herb rub.
  2. Step 2: Pat dry 1.5 lbs pork tenderloin and rub the herb mixture evenly over all sides.
  3. Step 3: On a large rimmed baking sheet, toss 1 lb halved Brussels sprouts with a drizzle of olive oil and a pinch of salt and pepper. Spread them out evenly.
  4. Step 4: Place the pork tenderloin on the baking sheet among the Brussels sprouts and roast for 25-30 minutes until the pork reaches an internal temperature of 145°F and Brussels sprouts are tender and caramelized.
  5. Step 5: Remove from oven and let the pork rest for 5 minutes before slicing. Serve sliced pork with roasted Brussels sprouts.

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Frequently asked questions

How long does Sheet Pan Herb-Crusted Pork Tenderloin with Roasted Brussels Sprouts take to make?

Total time is about 45 minutes (15 min prep + 30 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Sheet Pan Herb-Crusted Pork Tenderloin with Roasted Brussels Sprouts?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep (680g) pork tenderloin from drying out.

Can I substitute ingredients in Sheet Pan Herb-Crusted Pork Tenderloin with Roasted Brussels Sprouts?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Sheet Pan Herb-Crusted Pork Tenderloin with Roasted Brussels Sprouts for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

Is Sheet Pan Herb-Crusted Pork Tenderloin with Roasted Brussels Sprouts whole30?

Yes — this recipe is tagged whole30, gluten free based on its ingredient list. Always cross-check labels for packaged ingredients (sauces, broths, condiments) since formulations vary by brand.

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