Sheet Pan Lemon-Oregano Salmon with Roasted Vegetables

By AislePrompt Test Kitchen · Reviewed by AislePrompt Editorial · ·

Oven-roasted salmon fillets infused with lemon and oregano, accompanied by a colorful medley of tender roasted vegetables. This greek-inspired seafood ready in about 42 minutes pairs 6 oz each salmon fillets, lemon zest, lemon juice for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 380 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 15 min Cook: 27 min Serves 4 Greek cuisine 380 cal/serving
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Ingredients

Instructions

  1. Step 1: Preheat oven to 425°F. On a large rimmed baking sheet, toss 1 sliced medium red bell pepper, 1 sliced medium zucchini (1/2-inch rounds), and 1 sliced small red onion into thin wedges with 2 tbsp olive oil, 3 minced garlic cloves, 3/4 tsp salt, and 1/3 tsp black pepper. Spread evenly.
  2. Step 2: Roast the vegetables for 15 minutes, stirring halfway through for even browning.
  3. Step 3: While vegetables roast, brush 4 salmon fillets (6 oz each) with a mixture of 2 tbsp olive oil, 2 tbsp lemon juice, 1 tsp lemon zest, 2 tsp dried oregano, 3/4 tsp salt, and 2/3 tsp black pepper.
  4. Step 4: Remove the pan from oven, nestle the salmon fillets among the vegetables, skin side down, and return to the oven. Roast for an additional 10-12 minutes until salmon flakes easily with a fork.
  5. Step 5: Plate the salmon with the roasted vegetables and spoon any pan juices over the top to serve.

Frequently asked questions

How long does Sheet Pan Lemon-Oregano Salmon with Roasted Vegetables take to make?

Total time is about 42 minutes (15 min prep + 27 min cook). Most home cooks find this fits comfortably into a weeknight; double the batch on Sunday for two dinners.

How do I store leftover Sheet Pan Lemon-Oregano Salmon with Roasted Vegetables?

Cool to room temperature within 2 hours, then store in an airtight container in the fridge for up to 4 days. Reheat covered in a 350°F oven for 10-12 minutes, or microwave at 70% power in 60-second bursts to keep 6 oz each salmon fillets from drying out.

Can I substitute ingredients in Sheet Pan Lemon-Oregano Salmon with Roasted Vegetables?

Yes — most ingredients in this recipe have flexible swaps. For oil, use any neutral high-smoke-point oil (avocado, grapeseed, refined coconut). For aromatics, dried herbs at ⅓ the volume of fresh work in a pinch. The full ingredient list is shoppable on Instacart so you can see substitutes in real time.

How do I scale Sheet Pan Lemon-Oregano Salmon with Roasted Vegetables for a different number of people?

The recipe is written for 4 servings. Multiply each ingredient by (your serving target / 4). Cook time stays roughly the same up to 2x; for 3-4x batches, switch from a skillet to a sheet pan or stockpot so the food isn't crowded — overcrowding steams instead of browns.

What goes well with Sheet Pan Lemon-Oregano Salmon with Roasted Vegetables?

Greek seafood like this pair well with a simple grain (rice, couscous, or crusty bread), a quick salad with acid (lemon vinaigrette, pickled onions), and a pan sauce or yogurt-based dip. Tap "Plan a meal with the AI" to get specific side suggestions.

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