Oven-Roasted Cajun-Spiced Salmon with Garlic Butter

By AislePrompt Editorial · Published 2026-05-19 · Updated 2026-05-19

How this recipe was made — this recipe was drafted by AislePrompt's AI-assisted pipeline from technique templates and USDA-sourced nutrition data, and published by AislePrompt Editorial — see how AislePrompt recipes are drafted and published.

Salmon fillets roasted to flaky perfection with a zesty Cajun spice rub and finished with a drizzle of garlic butter. This American-inspired seafood recipe, ready in about 25 minutes, pairs salmon fillets, olive oil, paprika for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 420 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Prep: 10 min Cook: 15 min Serves 4 American cuisine 420 cal/serving

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Ingredients

4 pieces (6 oz each) salmon fillets
2 tbsp olive oil
1 tbsp paprika
1 tsp cayenne pepper
1 tsp garlic powder
1 tsp onion powder
1/2 tsp dried thyme
1 tsp salt
1/2 tsp black pepper
4 tbsp unsalted butter
3 cloves minced fresh garlic
2 tbsp chopped fresh parsley
4 lemon wedges

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Instructions

Step 1: Preheat oven to 400°F. In a small bowl, mix 1 tbsp paprika, 1 tsp cayenne pepper, 1 tsp garlic powder, 1 tsp onion powder, 1/2 tsp dried thyme, 1 tsp salt, and 1/2 tsp black pepper.
Step 2: Rub 2 tbsp olive oil evenly over 4 salmon fillets (6 oz each), then sprinkle the Cajun spice mix on all sides of the fillets.
Step 3: Place salmon skin-side down on a parchment-lined baking sheet and roast in the oven for 12-15 minutes until the salmon flakes easily with a fork.
Step 4: While salmon roasts, melt 4 tbsp unsalted butter in a small saucepan over medium heat. Add 3 minced garlic cloves and sauté for 2 minutes until fragrant but not browned.
Step 5: Remove garlic butter from heat and stir in 2 tbsp chopped fresh parsley.
Step 6: Drizzle the garlic butter over the roasted salmon fillets and serve with 4 lemon wedges for squeezing.