Oven-Baked Chicken Alfredo with Roasted Garlic and Spinach

By AislePrompt Editorial · Published 2026-05-10 · Updated 2026-05-10

Baked in a rich Alfredo sauce with roasted garlic and fresh spinach, finished with melted mozzarella and Parmesan cheese. This Italian-inspired chicken recipe, ready in about 60 minutes, pairs boneless skinless chicken breasts, olive oil, garlic cloves for a weeknight-friendly dinner that comes together with one pan and minimal cleanup. Each serving lands at about 560 calories and feeds 4, so it slots cleanly into a weekly meal plan and pairs well with a quick salad or grain on the side. Tap "Plan a meal with the AI" below to drop this recipe into your week and send the ingredients straight to Instacart. Nutrition values are approximate, calculated from USDA FoodData Central (fdc.nal.usda.gov) — verify against ingredient labels for any health-driven dietary plan.

Ingredients

• 4 pieces (about 6 oz each) boneless skinless chicken breasts
• 2 tbsp olive oil
• 6 whole garlic cloves
• 4 tbsp butter
• 3 tbsp all-purpose flour
• 2 cups whole milk
• 1 cup finely grated Parmesan cheese
• 1 cup shredded mozzarella cheese
• 4 cups packed fresh spinach
• 1 1/2 tsp salt
• 1 tsp black pepper
• 1 tsp dried Italian seasoning
• 1/4 tsp (optional) red pepper flakes

The instant-read thermometer we’d check this chicken with → Best Instant-Read Thermometers for 2026: Fast, Accurate Picks Under $100

Instructions

1. Step 1: Preheat oven to 375°F. Toss 6 whole garlic cloves with 1 tbsp olive oil, wrap in foil and roast for 20 minutes until soft and fragrant.
2. Step 2: Heat 2 tbsp olive oil in a large skillet over medium-high heat. Season 4 chicken breasts with 1 tsp salt, 1/2 tsp black pepper, and 1 tsp Italian seasoning. Sear chicken for 4 minutes per side until golden but not fully cooked, then set aside.
3. Step 3: In a saucepan over medium heat, melt 4 tbsp butter. Whisk in 3 tbsp flour and cook for 1-2 minutes until bubbling and light golden. Gradually add 2 cups whole milk, whisking constantly until sauce thickens and coats the back of a spoon, about 5 minutes.
4. Step 4: Squeeze roasted garlic cloves into the sauce and stir in 1 cup Parmesan cheese, 1 tsp salt, 1/2 tsp black pepper, and 1/4 tsp red pepper flakes. Remove from heat.
5. Step 5: In a large baking dish, arrange the seared chicken breasts and scatter 4 cups fresh spinach around them. Pour the Alfredo sauce evenly over chicken and spinach.
6. Step 6: Sprinkle 1 cup shredded mozzarella cheese on top. Bake uncovered for 20-25 minutes until chicken is cooked through (internal temp 165°F) and cheese is bubbly and golden.
7. Step 7: Let rest 5 minutes before serving to allow sauce to thicken slightly and flavors to meld.